l-Arginine grafted alginate hydrogel beads: A novel pH-sensitive system for specific protein delivery

Crosslinked Biodegradable Alginate Hydrogel Floating Beads for Stomach Site Specific Controlled Delivery of Metronidazole

The retention of drug delivery systems in the stomach for longer time is required to improve the bioavailability and therapeutic efficacy of the drugs used for the diseases associated with the stomach. In the present work, gastro-retentive floating beads of sodium alginate (SA) were prepared through ionotropic gelation with divalent Ca ions and covalent cross-linking with glutaraldehyde (GA). M...

Design and evaluate alginate nanoparticles as a protein delivery system

In recent years, encapsulation of drugs and antigens in hydrogels, specifically in calcium alginate particles, is an interesting and practical technique that was developed widespread. It is well known that alginate solution, under proper conditions, can form suitable nanoparticles as a promising carrier system, for vaccine delivery. The aim of this study was to synthesis alginate nanoparticles ...

Magnetic/pH-sensitive nanocomposite hydrogel based carboxymethyl cellulose –g- polyacrylamide/montmorillonite for colon targeted drug delivery

Objective(s): The main aim of current research was to develop a novel magnetically responsive hydrogel by radical polymerization of carboxymethyl cellulose (CMC) on acryl amide (Am) using N,N'-methylene bis acrylamide  (MBA)  as a crosslinking agent, potassium persulfate (KPS) as a free radical initiator, and  magnetic montmorillonite ( mMT)  nanoclay as nano-...

pH Sensitive Hydrogel Based Acrylic Acid for Controlled Drug Release

Hydrogels, due to their unique potentials such as high-water content and hydrophilicity are interest for the controlled release of drug molecules. The present study aims to create a controlled-release system through the preparation and characterization of hydrogels based on pH-sensitive polymers such as poly (acrylic acid). Poly (acrylic acid), p(AA), hydrogel has been synthesized by radical po...

protein bioconjugates: the novel delivery system for l-asparaginase